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Articles on Men's Health / Prostate

Progesterone Cream for Men

Highlights from the research of Dr. John Lee

Why Would A Man Need Supplemental Progesterone?

According to Dr. Lee, as a male ages, his progesterone level decreases just like it does in women. In women this decease occurs about the age of 35 and men about ten years later. When progesterone levels decrease, the male's 5 alpha reductase converts the testosterone to di-hydro testosterone which is useless at removing the prostate cancer cells that estradiol stimulates. Estradiol also stimulates the enlargement of the prostate. This allows the prostate gland to swell and enlarge and in many cases transform into prostate cancer.

Do Xenoestrogens (from the environment) Affect Men?

Men also make estrogen and estradiol, but in much lower amounts than women. The male hormone, testosterone, is antagonist to estradiol.

However, estrogen dominance caused by xenoestrogens is affecting men by raising their estrogen levels to dangerous levels.

Does Testosterone Cause Prostate Cancer?

Testosterone does NOT cause prostate cancer. If this were true 19 and 20 year old males would be developing prostate cancer as these are the individuals with the highest levels. This is obviously not the case, says Dr. Lee.

How Does Progesterone Protect Against Prostate Cancer?

Dr.Lee tells us that the prostate is embryologically similar to the female uterus. Hence it is subject to the estrogen dominance negative influences, just as the woman’s breast and uterus is. As we know, progesterone balances or opposes excess estrogen. The progesterone prevents the body from converting testosterone to di-hydro testosterone. It does this by inhibiting the enzyme 5-alpha reductase.


The dose of natural progesterone for men is 8 to 10 mg per day. Men do NOT need time off like women and can take the progesterone without taking any days off.

Dr. John R. Lee's Research:

Dr. Lee's has a large number of anecdotal stories of complete reversals of metastatic prostatic cancers. The clinical research is on-going. There is strong biochemical evidence to support this recommendation. The January 28, 1998 Journal of the American Medical Association had an article To die or not to die? showing that most cells in the body die through a noninflammatory, energy-dependent form of cell death called apoptosis. When the apoptosis mechanism is deranged by mutated cells, a wide array of disease can occur including cancer.

All cells, with the exception of brain and muscle cells, multiply continuously. The genes which regulates this cell growth are p53 and bcl2 . If the gene bcl2 dominates it will push cells to cancer. If gene p53 dominates the opposite will occur and the cell growth is controlled and the cancer do not occur.

The JAMA article article clearly shows that traditional chemotherapy using poisons to stop cell hyperplasia kill normal cells easier than cancer cells. The new idea promoted by the review is to find agents that activate p53 and deactivate bc12 in the hope for curing cancer.

Well, the good news is that research shows that Estradiol (estrogen) turns on the cancer gene bc12 and progesterone turns on the anti-cancer gene p53!!! Studies have shown that breast cancer cells do not multiply when women are on progesterone. These hormones also worked for cancer of the ovary and uterus and small cell lung cancer which is normally a very difficult cancer to treat with a horribly dismal diagnosis.

In Summary

Dr. Lee has stated that nearly all men should seriously consider natural progesterone replacement sometime in their 40s, or even earlier if they have a family history of prostate cancer.

ANOTHER NOTE: It has also been theorized that the use of natural progesterone has a reasonable likelihood of decreasing male balding, if this is a benefit of interest to you


At the University of Maryland in Baltimore, human prostate cells were shown to have progesterone receptor sites.

At Central Hospital University in Paris, progesterone was shown to inhibit the formation of DHT as well as binding of it to the prostate. DHT content in the prostate is the single most causative factor in prostate disease.

At the Institute of Clinical Chemistry in Bochum, Germany progesterone in human BPH tissue strongly reduced the activity of 5-alpha reductase.

At the University of Laval in Quebec it was clearly demonstrated that progesterone inhibited estrogen from binding to the prostate and progesterone receptors.